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Halfway by means of his vocation, Cees Dekker reinvented himself. Soon after many years of hardcore physics, he shifted his concentration to ‘nanobiology’ in the convert from the millennium. A time period he coined himself, as being a make any difference of actuality.

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Sculpting nano-electrodes using a transmission electron beam for electrical and geometrical characterization of nanoparticles.

That could be a aspiration of mine and we established to work by using a delicious dose of naivety. That is a thing that will probably yield impressive results in the for a longer time expression, but that doesn't make a difference. You shouldn't only want to operate over the concerns of tomorrow, and also about the thoughts from the day immediately after tomorrow.’

Our investigate ranges within the biophysics of DNA to artificial cells and outside of. You should take a look under with the spectrum of our present tasks.

What distinguishes biology from chemistry is the fact that these parts with each other make up a dwelling program. The trick of stated lifetime, I believe, lies from the interactions, the interaction of These molecules. The large question with regard to the origin of existence remains unanswered. How did we ever evolve from basic molecules into the incredibly elaborate techniques we see currently? We have no idea. I want to operate on These types of big, open issues.’

Nanopores stand for a sublime and multipurpose Software to evaluate single molecules. We study novel detection modes with strong-state nanopores in addition to numerous methods to measure proteins with nanopores. Jobs encompass the subsequent:

Knowing basic procedures regulating the spatial and dynamic organisation of your DNA in Are living cells.

‘The fantastically subtle way wherein features in character operate by no means ceases to amaze me. If we solve the puzzle of how everyday living arrived into getting, I anticipate that my amazement within the complexity of generation can have elevated and with it my awe with the greatness with the Creator.’

Example (four) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is proven in gray, the rim with the pore is highlighted in purple, as well as a 3D rendering from the movement with the DNA rod is shown.

2001, ceesdekker.net discovery of single-electron transistors at space temperature depending on nanotubes; realization of 1st logic circuits with carbon nanotube units; and discovery on the molecular framework of DNA mend enzymes with AFM

Visualization of unstained DNA nanostructures with Innovative in-emphasis transmission electron microscopy procedures

Strong-state nanopores have confirmed to become a astonishingly flexible probe for single-molecule Evaluation of DNA. I will explain many of our new results – exclusively DNA knots – and also our attempts to increase the capabilities of solid-point out nanopores even even further, from the route of single-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.